| First Author | Keane-Myers A | Year | 1995 |
| Journal | J Immunol | Volume | 154 |
| Issue | 4 | Pages | 1770-6 |
| PubMed ID | 7836761 | Mgi Jnum | J:23379 |
| Mgi Id | MGI:71114 | Doi | 10.4049/jimmunol.154.4.1770 |
| Citation | Keane-Myers A, et al. (1995) T cell subset-dependent modulation of immunity to Borrelia burgdorferi in mice. J Immunol 154(4):1770-6 |
| abstractText | The possible involvement of specific T cells in resolution of infections with Borrelia burgdorferi (Bb), the causative agent of human Lyme disease, has not been adequately studied. To investigate the potential role of T cell subsets in resistance, we have depleted mice of CD4+ and CD8+ T cell subsets in vivo by the administration of specific mAbs and have examined outcomes after infection with Bb. Our results indicate that CD4+ T cells are required for immunologic control of spirochete levels, because their depletion in both susceptible C3H/HeN and resistant BALB/c mice increased the severity of arthritis and the numbers of spirochetes found in joints and skin, as compared with Bb-infected mice treated with a control mAb. In contrast, the CD8+ T cell compartment, particularly in susceptible C3H/HeN mice, appears to promote the disease process, possibly by interfering with the generation of protective immunity, as abrogation of this subset in vivo led to a reduction in both arthritis and in spirochete levels found in joints and skin when compared with Bb-infected control mice. Our inability to establish a correlation between resistance and Bb-specific IgG Ab levels in these mice raises the possibility that Ab-independent mechanisms are important in protection. These findings suggest that the final outcome in Bb-infected hosts may be the net effect of antagonistic influences exerted by CD4+ and CD8+ T cell subsets. |
