| First Author | Rademaekers A | Year | 1995 |
| Journal | Eur J Immunol | Volume | 25 |
| Issue | 2 | Pages | 623-6 |
| PubMed ID | 7533095 | Mgi Jnum | J:23270 |
| Mgi Id | MGI:71036 | Doi | 10.1002/eji.1830250247 |
| Citation | Rademaekers A, et al. (1995) Regulation of an anti-polysaccharide immune response in BALB/c mice through a tight t and b lymphocyte idiotypic connection. Eur J Immunol 25(2):623-626 |
| abstractText | The isotype expression in the J558 idiotype-associated humoral immune response against alpha(1 --> 3)-dextran in BALB/c mice is controlled by idiotype-specific T cells which silence in situ B lymphocytes primed and committed to an IgG response. This leads to a restriction of the type II thymus-independent response to the sole production of IgM antibodies. The availability of the T cell receptor (TcR) alpha and beta sequences for such a regulatory T cell clone allows the investigation of the degree of heterogeneity of the TcR usage of these T cells. It is found that all alpha(1 --> 3)-dextran-primed BALB/c mice use a very similar, possibly identical TcR. This suggests a tight, possibly genetically programmed, interaction between the J558 idiotype-bearing dextran-specific B cells and their idiotype-specific regulatory T cell counterparts. |
