| First Author | Stanley SL Jr | Year | 1995 |
| Journal | Infect Immun | Volume | 63 |
| Issue | 4 | Pages | 1587-90 |
| PubMed ID | 7890426 | Mgi Jnum | J:25140 |
| Mgi Id | MGI:72868 | Doi | 10.1128/iai.63.4.1587-1590.1995 |
| Citation | Stanley SL Jr, et al. (1995) Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice. Infect Immun 63(4):1587-90 |
| abstractText | Evidence from in vitro studies suggest that the Entamoeba histolytica cysteine proteinase plays a role in the tissue lysis and cytopathic effects seen in invasive amebiasis. We used affinity-purified antibodies against a recombinant E. histolytica cysteine proteinase to demonstrate that the proteinase is present extracellularly in amebic liver abscesses in mice with severe combined immunodeficiency (SCID mice). Treatment of E. histolytica trophozoites with specific cysteine proteinase inhibitor E-64 blocked or greatly reduced liver abscess formation at 48 h in SCID mice. Our study suggests an important role for a functional cysteine proteinase in amebic liver abscess formation. |
