| First Author | Pinto HC | Year | 1995 |
| Journal | Gastroenterology | Volume | 108 |
| Issue | 4 | Pages | 967-74 |
| PubMed ID | 7698612 | Mgi Jnum | J:25128 |
| Mgi Id | MGI:72857 | Doi | 10.1016/0016-5085(95)90191-4 |
| Citation | Pinto HC, et al. (1995) The distribution of endocrine cell types of the gastrointestinal mucosa in genetically diabetic (db/db) mice. Gastroenterology 108(4):967-74 |
| abstractText | BACKGROUND/AIMS: Genetically diabetic (db/db) mice are a model for non-insulin-dependent diabetes in humans. The gastrointestinal tracts in 12-week-old db/db and nondiabetic control (db/+) mice were studied with particular emphasis on the endocrine cells. METHODS: Immunocytochemical and quantification techniques were used to localize and determine the number of cells containing serotonin and various regulatory peptides. RESULTS: In the antrum, the gastrin- and serotonin-immunoreactive cells were increased in number. In the large intestine, the enteroglucagon and the peptide tyrosine-immunoreactive cells were increased in number, whereas there were fewer serotonin-immunoreactive cells. There were also fewer somatostatin-immunoreactive cells in most gastrointestinal regions. In diabetic mice, the intestine was longer and its mucosa thicker than in control mice. CONCLUSIONS: The results indicate that the genetic diabetic (db/db) condition exerts a significant influence on the gastrointestinal tract and on the endocrine cell systems studied. The observed alterations may reflect the effect of indirect factors rather than the diabetes per se. |
