| First Author | Zimonjic DB | Year | 1995 |
| Journal | Oncogene | Volume | 10 |
| Issue | 6 | Pages | 1235-7 |
| PubMed ID | 7700649 | Mgi Jnum | J:25152 |
| Mgi Id | MGI:72880 | Citation | Zimonjic DB, et al. (1995) Localization of the human HER4/erbB-4 gene to chromosome 2. Oncogene 10(6):1235-7 |
| abstractText | The HER4/erbB-4 gene has been isolated as the fourth member of the human EGFR subfamily of tyrosine kinases and has been reported to encode a receptor for NDF/heregulin. In the present study we determined the chromosomal location of the HER4/erbB-4 gene within the human genome. Using human cDNA probes in fluorescence in situ hybridization (FISH), we mapped the HER4/erbB-4 gene to human chromosome 2q33.3-34. This finding established that also the HER4/erbB-4 gene is located in close vicinity of homeobox and collagen gene loci, as is the case for the related EGFR, erbB-2/neu and erbB-3. Aberrations of this chromosomal region associated with T cell leukemias and lymphomas as well as alveolar rhabdomyosarcomas raise the possibility that HER4/erbB-4 might be activated in these tumour types. |
