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Publication : Corticosterone, adrenal and spleen weight in mice after tail bleeding, and its effect on nearby animals.

First Author  Tuli JS Year  1995
Journal  Lab Anim Volume  29
Issue  1 Pages  90-5
PubMed ID  7707684 Mgi Jnum  J:31562
Mgi Id  MGI:79319 Doi  10.1258/002367795780740339
Citation  Tuli JS, et al. (1995) Corticosterone, adrenal and spleen weight in mice after tail bleeding, and its effect on nearby animals. Lab Anim 29(1):90-5
abstractText  Experiments were performed in mice to study if stress was involved in tail bleeding and to investigate any transmittable signal at killing. A second study looked at the time taken to recover from stress elicited by these procedures. Corticosterone levels were significantly higher in mice immediately after the completion of tail bleeding than in control mice (P < 0.05) suggesting that tail bleeding in mice was stressful. This study did not show any evidence for an odour or sound being released during killing or tail bleeding as there was no significant effect on corticosterone levels in mice present in the same room at the time these procedures were carried out. Corticosterone levels in mice killed on days 1, 3, and 7 after tail bleeding were significantly lower (P < 0.05) than the average corticosterone level in tail blood on day 1, indicating that mice recovered within 24 h from the stress of tail bleeding.
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