| First Author | Papavasiliou F | Year | 1995 |
| Journal | Science | Volume | 268 |
| Issue | 5209 | Pages | 408-11 |
| PubMed ID | 7716544 | Mgi Jnum | J:24496 |
| Mgi Id | MGI:72235 | Doi | 10.1126/science.7716544 |
| Citation | Papavasiliou F, et al. (1995) The role of Ig beta in precursor B cell transition and allelic exclusion. Science 268(5209):408-11 |
| abstractText | Lymphocytes express multicomponent receptor complexes that mediate diverse antigen-dependent and antigen-independent responses. Despite the central role of antigen-independent events in B cell development, little is known about the mechanisms by which they are initiated. The association between the membrane immunoglobulin (Ig) M heavy chair (micron) and the Ig alpha-Ig beta heterodimer is now shown to be essential in inducing both the transition from progenitor to precursor B cells and subsequent allelic exclusion in transgenic mice. The cytoplasmic domain of Ig beta is sufficient to induce these early antigen-independent events by a mechanism that requires conserved tyrosine residues in this protein. |
