| First Author | Gueth-Hallonet C | Year | 1994 |
| Journal | Development | Volume | 120 |
| Issue | 11 | Pages | 3289-99 |
| PubMed ID | 7720568 | Mgi Jnum | J:21620 |
| Mgi Id | MGI:69555 | Doi | 10.1242/dev.120.11.3289 |
| Citation | Gueth-Hallonet C, et al. (1994) Gp330 is specifically expressed in outer cells during epithelial differentiation in the preimplantation mouse embryo. Development 120(11):3289-99 |
| abstractText | During preimplantation development of the mouse embryo, a layer of outer cells differentiates into a perfect epithelium, the trophectoderm. The divergence between the trophectoderm and the inner cell mass takes place from the 8-cell stage to the 64-cell stage and precedes their commitment at the blastocyst stage. In this work, we have investigated the expression of gp330, a 330 x 10(3) M(r) glycoprotein found in clathrin-coated areas of the plasma membrane of some epithelial cells characterized by a high level of endocytic activity. Our results show that gp330 is first synthesized in 16-cell stage embryos and that its appearance is restricted to outer cells until the blastocyst stage. Furthermore, its expression is repressed in inner cells at a post-transcriptional level, probably through the development of extensive cell-cell contacts. |
