| First Author | Ruiz-Bravo A | Year | 1995 |
| Journal | Immunol Lett | Volume | 44 |
| Issue | 1 | Pages | 41-4 |
| PubMed ID | 7721342 | Mgi Jnum | J:22969 |
| Mgi Id | MGI:70837 | Doi | 10.1016/0165-2478(94)00185-t |
| Citation | Ruiz-Bravo A, et al. (1995) The enhancement of growth of a syngeneic plasmacytoma in BALB/c mice by pristane priming is not due to immunosuppressive effects on antibody-forming cell or mitogen-responsive splenocytes. Immunol Lett 44(1):41-4 |
| abstractText | The effects of pristane on some immunity parameters in BALB/c mice were studied. The intraperitoneal administration of a single dose of pristane induced a strong inflammatory reaction that lasted longer than 10 days. When mice were immunized with sheep erythrocytes 10 days after pristane administration, the response of hemolytic IgM-forming cells was increased and that of hemolytic IgG-forming cells was decreased; however, the total number of antibody-forming cells did not change. The proliferative response of splenocytes to concanavalin A was increased in mice that received pristane 10 days earlier. Development of the syngeneic NS1 plasmacytoma was enhanced by administration of pristane 2 days or 10 days before tumor transplantation. We concluded that enhancement of plasmacytoma development was not due to immunosuppressive properties of pristane but to other factors such as ascites induction. |
