| First Author | Courtier B | Year | 1995 |
| Journal | Proc Natl Acad Sci U S A | Volume | 92 |
| Issue | 8 | Pages | 3531-5 |
| PubMed ID | 7536936 | Mgi Jnum | J:24400 |
| Mgi Id | MGI:72166 | Doi | 10.1073/pnas.92.8.3531 |
| Citation | Courtier B, et al. (1995) Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist. Proc Natl Acad Sci U S A 92(8):3531-5 |
| abstractText | During early mammalian embryogenesis, one of the two X chromosomes in somatic cells of the female becomes inactivated through a process that is thought to depend on a unique initiator region, the X-chromosome inactivation center (Xic). The recently characterized Xist sequence (X-inactive-specific transcript) is thought to be a possible candidate for Xic. In mice a further genetic element, the X chromosome-controlling element (Xce), is also known to influence the choice of which of the two X chromosomes is inactivated. We report that a region of the mouse X chromosome lying 15 kb distal to Xist contains several sites that show hypermethylation specifically associated with the active X chromosome. Analysis of this region in various Xce strains has revealed a correlation between the strength of the Xce allele carried and the methylation status of this region. We propose that such a region could be involved in the initial stages of the inactivation process and in particular in the choice of which of the two X chromosomes present in a female cell will be inactivated. |
