| First Author | Galbreath E | Year | 1995 |
| Journal | J Neuropathol Exp Neurol | Volume | 54 |
| Issue | 3 | Pages | 339-49 |
| PubMed ID | 7745433 | Mgi Jnum | J:26936 |
| Mgi Id | MGI:74360 | Doi | 10.1097/00005072-199505000-00007 |
| Citation | Galbreath E, et al. (1995) Overexpression of TGF-beta 1 in the central nervous system of transgenic mice results in hydrocephalus. J Neuropathol Exp Neurol 54(3):339-49 |
| abstractText | Transforming growth factor beta (TGF-beta) has been proposed to play a number of roles in central nervous system (CNS) development and response to injury. To test these proposals, transgenic mice were generated which overproduce TGF-beta 1 in the CNS. Surprisingly, these mice developed severe hydrocephalus and died between birth and 3 weeks of age. Ovary transplantation from an affected female founder has permitted perpetuation of one of the lines as a hydrocephalus model whose genetic defect is known. These results also demonstrate that the developing CNS is highly sensitive to TGF-beta, and suggest a role for aberrant expression of TGF-beta in the pathogenesis of developmental disease of the CNS. |
