| First Author | Daneri-Navarro A | Year | 1995 |
| Journal | Biomed Pharmacother | Volume | 49 |
| Issue | 1 | Pages | 39-44 |
| PubMed ID | 7749078 | Mgi Jnum | J:24892 |
| Mgi Id | MGI:72558 | Doi | 10.1016/0753-3322(96)82576-5 |
| Citation | Daneri-Navarro A, et al. (1995) L-5178-Y lymphoma associated immunosuppression in Balb/c mice. Biomed Pharmacother 49(1):39-44 |
| abstractText | Lymphoma L-5178-Y bearing Balb/c mice were unable to mount a delayed-type hypersensitivity reaction to dinitrofluorobenzene (DNFB). A suppressor factor present in the ascitis of these mice inhibited the response if given during DNFB sensitization, but not during challenge. The factor was not present in lymphoma-bearing Balb/c nu/nu mice. It appeared to be a 35-66 kDa protein. Non-specific esterase staining indicated that the spleens of tumor-bearing and ascitis-injected mice contained a large excess of macrophages. Our observation that the suppressor factor prevented the very start of the immune response may indicate why immunostimulation is difficult to obtain in cancer bearing hosts. |
