| First Author | Agulnik SI | Year | 1995 |
| Journal | Genomics | Volume | 25 |
| Issue | 1 | Pages | 214-9 |
| PubMed ID | 7774921 | Mgi Jnum | J:22778 |
| Mgi Id | MGI:70666 | Doi | 10.1016/0888-7543(95)80128-9 |
| Citation | Agulnik SI, et al. (1995) Conservation of the T-box gene family from Mus musculus to Caenorhabditis elegans. Genomics 25(1):214-9 |
| abstractText | Recently, a novel family of genes with a region of homology to the mouse T locus, which is known to play a crucial, and conserved, role in vertebrate development, has been discovered. The region of homology has been named the T-box. The T-box domain of the prototypical T locus product is associated with sequence-specific DNA binding activity. In this report, we have characterized four members of the T-box gene family from the nematode Caenorhabditis elegans. All lie in close proximity to each other in the middle of chromosome III. Homology analysis among all completely sequenced T-box products indicates a larger size for the conserved T-box domain (166 to 203 residues) than previously reported. Phylogenetic analysis suggests that one C. elegans T-box gene may be a direct ortholog of the mouse Tbx2 and Drosophila omb genes. The accumulated data demonstrate the ancient nature of the T-box gene family and suggest the existence of at least three separate T-box-containing genes in a common early metazoan ancestor to nematodes and vertebrates. |
