| First Author | Mason KA | Year | 1995 |
| Journal | Pigment Cell Res | Volume | 8 |
| Issue | 1 | Pages | 46-52 |
| PubMed ID | 7792254 | Mgi Jnum | J:24890 |
| Mgi Id | MGI:72556 | Doi | 10.1111/j.1600-0749.1995.tb00773.x |
| Citation | Mason KA, et al. (1995) The identification and partial cloning by PCR of the gene for tyrosinase-related protein-1 in the Mexican axolotl. Pigment Cell Res 8(1):46-52 |
| abstractText | The tyrosinase gene family is currently composed of three members, tyrosinase and two tyrosinase-related proteins, TRP-1 and TRP-2. These three gene products have all been found to act in the synthesis of melanin pigments with the enzyme tyrosinase catalyzing the initial rate-limiting steps. Thus far these genes have primarily been analyzed in higher vertebrates. We have used degenerate PCR primers to isolate a large fragment of an axolotl tyrosinase-related protein. Sequence analysis of the entire 1,057-bp fragment isolated indicates a high degree of similarity to the mouse TRP-1, the product of the brown locus. Phylogenetic analysis supports the conclusion that the fragment isolated corresponds to the axolotl TRP-1 homolog. This is the first TRP-1 gene to be identified in an amphibian species. |
