| First Author | Naik YS | Year | 1995 |
| Journal | J Egypt Soc Parasitol | Volume | 25 |
| Issue | 1 | Pages | 157-63 |
| PubMed ID | 7602158 | Mgi Jnum | J:28360 |
| Mgi Id | MGI:75978 | Citation | Naik YS, et al. (1995) Intensity of Schistosoma mansoni infection determines alterations in hepatic drug metabolism. J Egypt Soc Parasitol 25(1):157-63 |
| abstractText | Zoxazolamine paralysis times have been used as a probe to measure the activities of cytochrome P450 1A1 in mice in vivo. The results indicate that male and female mice of the BALB/c and CBA/J strain do not show altered paralysis times if infected with less than 4 worm pairs. Alterations were observed only in animals harbouring more than 5 worm pairs irrespective of the sex or strain of mouse being used. The study has extended the findings of other workers showing that mice infected with fewer than 4-5 worm pairs of S. mansoni do not show any alteration in the metabolism of pentobarbital in vivo. |
