| First Author | Lafuse WP | Year | 1995 |
| Journal | Cell Immunol | Volume | 163 |
| Issue | 2 | Pages | 187-90 |
| PubMed ID | 7606791 | Mgi Jnum | J:26702 |
| Mgi Id | MGI:74135 | Doi | 10.1006/cimm.1995.1115 |
| Citation | Lafuse WP, et al. (1995) The cytotoxic T lymphocyte gene FIBLP with homology to fibrinogen beta and gamma subunits is also induced in mouse macrophages by IFN-gamma. Cell Immunol 163(2):187-90 |
| abstractText | To identify genes induced in mouse macrophages by IFN-gamma, a cDNA subtraction library of IFN-gamma-induced genes was screened. One of the clones, 36F2, was identified by DNA sequencing as the FIBLP gene. The FIBLP (fibrinogen-like protein) gene is a T-lymphocyte-specific gene that is expressed in mouse cytotoxic T lymphocytes but not in helper T lymphocytes or B lymphocytes. The protein sequence shows a high homology to fibrinogen beta and gamma subunits. The FIBLP gene is not expressed in unstimulated mouse peritoneal macrophages but is induced by IFN-gamma to high levels. FIBLP mRNA is detected by 1 hr after the addition of IFN-gamma and maximal levels are reached by 12 hr. Expression of FIBLP mRNA was not induced by IL-2, IL-4, IL-10, or TNF-alpha. Though the function of this gene is unknown, its expression in both cytotoxic T lymphocytes and activated macrophages suggests that FIBLP may play an as yet undefined role in the cytotoxic function of these cells. |
