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Publication : Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13.

First Author  Dietrich WF Year  1995
Journal  Genomics Volume  26
Issue  3 Pages  443-50
PubMed ID  7607666 Mgi Jnum  J:25245
Mgi Id  MGI:72971 Doi  10.1016/0888-7543(95)80161-e
Citation  Dietrich WF, et al. (1995) Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13. Genomics 26(3):443-50
abstractText  The intracellular pathogen Legionella pneumophila is unable to replicate in macrophages derived from most inbred mouse strains. Here, we report the mapping of a gene, called Lgn1, that determines whether mouse macrophages are permissive for the intracellular replication of L. pneumophila. Although Lgn1 has been previously reported to map to mouse chromosome 15, we show here that it actually maps to chromosome 13, between D13Mit128 and D13Mit70. In the absence of any regional candidates for Lgn1, this map position will facilitate positional cloning attempts directed at this gene.
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