| First Author | Kips JC | Year | 1995 |
| Journal | Int Arch Allergy Immunol | Volume | 107 |
| Issue | 1-3 | Pages | 115-8 |
| PubMed ID | 7613115 | Mgi Jnum | J:36636 |
| Mgi Id | MGI:84063 | Doi | 10.1159/000236947 |
| Citation | Kips JC, et al. (1995) Importance of interleukin-4 and interleukin-12 in allergen-induced airway changes in mice. Int Arch Allergy Immunol 107(1-3):115-8 |
| abstractText | T helper 2 (Th2)-like cells are thought to play a crucial role in the pathogenesis of atopic asthma. In this study, we attempted to evaluate the in vivo effect of suppressing Th2 cell development on allergen-induced airway changes. Repeated exposure of actively sensitized C57Bl/6 mice to aerosolized ovalbumin (OA) causes, in comparison to saline-exposed control animals, synthesis of specific IgE, increase of eosinophils in bronchoalveolar lavage fluid and airway hyperresponsiveness. These effects are not observed in OA-exposed, sensitized IL-4-knockout mice. Likewise, these effects are inhibited in OA-exposed C57Bl/6 mice treated with IL-12 during initial antigen exposure. These results suggest that suppressing Th2 cell development in vivo might have profound inhibitory effects on allergen-induced airway changes. |
