| First Author | Galli SJ | Year | 1995 |
| Journal | Int Arch Allergy Immunol | Volume | 107 |
| Issue | 1-3 | Pages | 51-3 |
| PubMed ID | 7542101 | Mgi Jnum | J:28640 |
| Mgi Id | MGI:76161 | Doi | 10.1159/000236928 |
| Citation | Galli SJ, et al. (1995) Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the c-kit receptor. Int Arch Allergy Immunol 107(1-3):51-3 |
| abstractText | Stem cell factor (SCF), the ligand for the receptor (SCFR) that is encoded by the c-kit proto-oncogene, has many important effects in mouse and human mast cell development, survival, and function. SCF can promote mast cell survival by suppressing apoptosis, induce mast cell hyperplasia in murine rodents, experimental primates and humans, directly induce SCFR-dependent mast cell mediator release, and significantly modulate the extent of mast cell activation by Fc epsilon RI-dependent mechanisms. These findings raise several clinical issues and, in some cases, point to potentially significant therapeutic opportunities. |
