| First Author | Heath WR | Year | 1995 |
| Journal | Eur J Immunol | Volume | 25 |
| Issue | 6 | Pages | 1617-23 |
| PubMed ID | 7614990 | Mgi Jnum | J:26529 |
| Mgi Id | MGI:73974 | Doi | 10.1002/eji.1830250622 |
| Citation | Heath WR, et al. (1995) Expression of two T cell receptor alpha chains on the surface of normal murine T cells. Eur J Immunol 25(6):1617-23 |
| abstractText | We have previously reported that a subset of T cells in T cell receptor (TCR)-transgenic mice may express two different alpha chains on their surface. The expression of two functional alpha chains has also been demonstrated for human peripheral blood T cells. In this report, we show that a proportion of normal murine lymph node T cells express two functional alpha chains on their surface. The extrapolated frequency of these cells present in the normal repertoire ranges from 7-21%, with an average of 15%. Our analysis of a small number of antigen-specific T cell clones suggests that the frequency of antigen-responsive cells expressing two surface alpha chains is relatively low. This raises the possibility that dual alpha chain T cells may have a selective disadvantage in responding to specific antigen. |
