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Publication : Exogenous tumor necrosis factor alpha and interleukin-1 alpha increase resistance to Salmonella typhimurium: efficacy is influenced by the Ity and Lps loci.

First Author  Morrissey PJ Year  1995
Journal  Infect Immun Volume  63
Issue  8 Pages  3196-8
PubMed ID  7622247 Mgi Jnum  J:29313
Mgi Id  MGI:76842 Doi  10.1128/iai.63.8.3196-3198.1995
Citation  Morrissey PJ, et al. (1995) Exogenous tumor necrosis factor alpha and interleukin-1 alpha increase resistance to Salmonella typhimurium: efficacy is influenced by the Ity and Lps loci. Infect Immun 63(8):3196-8
abstractText  Interleukin-1 alpha (IL-1 alpha) or tumor necrosis factor alpha (TNF-alpha) administered prior to infection with Salmonella typhimurium increases survival in mice that are Ityr, not in susceptible Lpsd or Itys mice. Combined IL-1 alpha and TNF-alpha pretreatment results in greater survival than that seen with either cytokine alone in Ityr mice. Treatment after infection with TNF-alpha and/or IL-1 alpha increases the mean time to death but not the survival fraction of Lpsd mice and was ineffective in either Ityr or Itys mice.
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