First Author | Morrissey PJ | Year | 1995 |
Journal | Infect Immun | Volume | 63 |
Issue | 8 | Pages | 3196-8 |
PubMed ID | 7622247 | Mgi Jnum | J:29313 |
Mgi Id | MGI:76842 | Doi | 10.1128/iai.63.8.3196-3198.1995 |
Citation | Morrissey PJ, et al. (1995) Exogenous tumor necrosis factor alpha and interleukin-1 alpha increase resistance to Salmonella typhimurium: efficacy is influenced by the Ity and Lps loci. Infect Immun 63(8):3196-8 |
abstractText | Interleukin-1 alpha (IL-1 alpha) or tumor necrosis factor alpha (TNF-alpha) administered prior to infection with Salmonella typhimurium increases survival in mice that are Ityr, not in susceptible Lpsd or Itys mice. Combined IL-1 alpha and TNF-alpha pretreatment results in greater survival than that seen with either cytokine alone in Ityr mice. Treatment after infection with TNF-alpha and/or IL-1 alpha increases the mean time to death but not the survival fraction of Lpsd mice and was ineffective in either Ityr or Itys mice. |