| First Author | Furuta Y | Year | 1995 |
| Journal | Jpn J Cancer Res | Volume | 86 |
| Issue | 6 | Pages | 540-5 |
| PubMed ID | 7622418 | Mgi Jnum | J:27745 |
| Mgi Id | MGI:75230 | Doi | 10.1111/j.1349-7006.1995.tb02432.x |
| Citation | Furuta Y, et al. (1995) Ovarian teratomas in mice lacking the protooncogene c-mos. Jpn J Cancer Res 86(6):540-5 |
| abstractText | Parthenogenesis has been suggested to be tightly coupled with development of ovarian teratomas. Indeed, ovarian tumors developed in c-mos-deficient female mice, which are characterized by the parthenogenetic activation of oocytes. The tumors appeared at a frequency of 30% between 4 and 8 months of age, and did not develop in younger or older mice. Most of the tumors were benign and consisted of multi-focal cysts most notably with mature ectodermal components, but also with mesodermal and endodermal components. One among 17 tumors observed consisted of extra-embryonic tissues alone, and two bore malignant components with metastasis to peritoneal organs. The results strongly suggest the involvement of c-mos mutations in human germ cell tumors. |
