| First Author | Markel PD | Year | 1995 |
| Journal | Alcohol Clin Exp Res | Volume | 19 |
| Issue | 2 | Pages | 299-304 |
| PubMed ID | 7625561 | Mgi Jnum | J:25696 |
| Mgi Id | MGI:73406 | Doi | 10.1111/j.1530-0277.1995.tb01506.x |
| Citation | Markel PD, et al. (1995) Use of repeated measures in an analysis of ethanol-induced loss of righting reflex in inbred long-sleep and short-sleep mice. Alcohol Clin Exp Res 19(2):299-304 |
| abstractText | We present a repeated-measures analysis of ethanol-induced loss of righting reflex (LRR) in Inbred Long-Sleep (ILS) and Inbred Short-Sleep (ISS) strains of mice and their F1 and F2 cross progeny. Mice were administered a 4.1 g/kg intraperitoneal dose of ethanol at two times, 7-10 days apart. Repeatability is nonsignificant in ILS, ISS, and F1 mice, but is highly significant (0.47, p < 0.01) in the F2 mice. Mean LRR does not differ between trials 1 and 2, with the exception of the ISS strain in which the interaction of sex with LRR sensitization is significant. This two-trial method leads to increased accuracy of genotype assessment for pharmacological or behavioral traits where trial 1 does not influence the outcome of trial 2. The repeated-measures design facilitates novel analyses of the duration of LRR, and results suggest that most environmental variance for LRR is due to nonreplicable influences. |
