| First Author | Kanazawa S | Year | 1995 |
| Journal | Biochem Biophys Res Commun | Volume | 215 |
| Issue | 2 | Pages | 438-45 |
| PubMed ID | 7487975 | Mgi Jnum | J:29247 |
| Mgi Id | MGI:76778 | Doi | 10.1006/bbrc.1995.2484 |
| Citation | Kanazawa S, et al. (1995) Integrin stimulation decreases tyrosine phosphorylation and activity of focal adhesion kinase in thymocytes. Biochem Biophys Res Commun 215(2):438-45 |
| abstractText | FAK, focal adhesion kinase, is expressed in a variety of cell types and has been suggested to transduce signals brought about by integrin-extracellular matrix (ECM) interactions. Integrin stimulation increases tyrosine phosphorylation and activity of FAK in all the cells examined to date. In contrast, in thymocytes stimulation of VLA-4 (alpha 4 beta 1) and LFA-1 (alpha L beta 2) resulted in a marked decrease in tyrosine phosphorylation and activity of FAK. |
