| First Author | Bonner CA | Year | 1995 |
| Journal | Genomics | Volume | 28 |
| Issue | 2 | Pages | 206-11 |
| PubMed ID | 8530027 | Mgi Jnum | J:28015 |
| Mgi Id | MGI:75648 | Doi | 10.1006/geno.1995.1132 |
| Citation | Bonner CA, et al. (1995) Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. Genomics 28(2):206-11 |
| abstractText | The human CDX1 gene has been isolated from a small intestine cDNA library using a murine Cdx1 cDNA probe. The nucleotide sequence of CDX1 is 81% identical to murine Cdx1 and predicts a 265-amino-acid protein with 85% identity to the mouse protein (98% identity, including conservative amino acid changes). The CDX1 locus has been mapped to a cosmid contig from chromosome 5q31-q33, placing CDX1 approximately 100 kb distal to CSFIR. Expression of CDX1 in adults appears to be limited to the intestine and colon by Northern analysis, suggesting a possible role in the terminal differentiation of the intestine. Further analysis of CDX1 should elucidate the function of caudal-type homeobox genes in human development. |
