| First Author | Bellaby T | Year | 1995 |
| Journal | Parasitology | Volume | 111 ( Pt 3) |
| Pages | 353-7 | PubMed ID | 7567103 |
| Mgi Jnum | J:29426 | Mgi Id | MGI:76960 |
| Doi | 10.1017/s0031182000081907 | Citation | Bellaby T, et al. (1995) Isolates of Trichuris muris vary in their ability to elicit protective immune responses to infection in mice. Parasitology 111(Pt 3):353-7 |
| abstractText | Much of what is currently known of the host-parasite interaction between mice and the parasitic nematode Trichuris muris has come from experiments using a single parasite isolate (E/N). This isolate has been compared with 2 others which, on morphological criteria, belong to the same species. In 3 inbred strains of mouse that show distinct, genetically determined response phenotypes, there was a consistent pattern in terms of parasite survival time regardless of host strain, E/K worms being expelled early, E/N expelled later and S worms very late or not at all. High-responder CBA mice expelled E/K and E/N worms earlier than low-responder C57 B1/10 mice. B10.BR mice were permissive to S isolate infection, mounted a very late response to E/N worms but expelled E/K worms effectively by day 25. The differential response of mice to these isolates provides an experimental system for identifying the basis of variation in this host-parasite relationship. |
