| First Author | Rowitch DH | Year | 1995 |
| Journal | Mech Dev | Volume | 52 |
| Issue | 1 | Pages | 3-8 |
| PubMed ID | 7577673 | Mgi Jnum | J:27755 |
| Mgi Id | MGI:75240 | Doi | 10.1016/0925-4773(95)00380-j |
| Citation | Rowitch DH, et al. (1995) Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1. Mech Dev 52(1):3-8 |
| abstractText | In the Drosophila embryo, activation of wingless and engrailed in the parasegment requires paired, a member of the Pax family of transcription factors. We have explored the possible conservation of this regulatory hierarchy in the developing mouse brain. We find that Pax-2 is expressed prior to somite formation in the presumptive mid/hindbrain region. Shortly thereafter, Wnt-1 (the wingless orthologue) and Engrailed-1 are expressed in overlapping regions within the Pax-2 domain. Pax-5 expression commences later, at the 3-somite stage. Thus, the spatial and temporal expression of Pax-2 is consistent with a possible regulatory role in the activation of Wnt-1 and En-1. |
