| First Author | Iler N | Year | 1995 |
| Journal | Mech Dev | Volume | 53 |
| Issue | 1 | Pages | 87-96 |
| PubMed ID | 8555114 | Mgi Jnum | J:29062 |
| Mgi Id | MGI:76586 | Doi | 10.1016/0925-4773(95)00427-0 |
| Citation | Iler N, et al. (1995) A single homeodomain binding site restricts spatial expression of Wnt-1 in the developing brain. Mech Dev 53(1):87-96 |
| abstractText | In this study we investigate the molecular mechanisms that are responsible for the restricted expression of Wnt-1 during embryogenesis. We report that a single homeodomain binding site, HBS1, within the Wnt-1 enhancer contributes to appropriate spatial expression of Wnt-1 in the developing nervous system. This HBS1 site may be required for repressing Wnt-1 expression in the developing forebrain since specific mutations of this site result in an extension of the rostral boundary of Wnt-1/lacZ staining in transgenic embryos. We further demonstrate that a subset of homeodomain proteins expressed in the forebrain (i.e., Dix2, Emx2) interact specifically with HBS1. These findings suggest that these (or related) homeodomain proteins may regulate expression of Wnt-1 during normal brain development by interacting with the HBS1 site in the Wnt-1 enhancer. |
