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Publication : Requirement for Xist in X chromosome inactivation.

First Author  Penny GD Year  1996
Journal  Nature Volume  379
Issue  6561 Pages  131-7
PubMed ID  8538762 Mgi Jnum  J:30632
Mgi Id  MGI:78135 Doi  10.1038/379131a0
Citation  Penny GD, et al. (1996) Requirement for Xist in X chromosome inactivation [see comments]. Nature 379(6561):131-7
abstractText  The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.
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