| First Author | Hernández-Munain C | Year | 1996 |
| Journal | J Exp Med | Volume | 183 |
| Issue | 1 | Pages | 289-93 |
| PubMed ID | 8551234 | Mgi Jnum | J:30642 |
| Mgi Id | MGI:78145 | Doi | 10.1084/jem.183.1.289 |
| Citation | Hernandez-Munain C, et al. (1996) Regulation of T cell receptor delta gene rearrangement by c-Myb. J Exp Med 183(1):289-93 |
| abstractText | Developmental activation of VDJ recombination at the T cell receptor (TCR) delta locus is controlled by an intronic transcriptional enhancer (E delta). Transcriptional activation by E delta is dependent on c-Myb. To determine whether c-Myb plays a role in the activation of TCR-delta gene rearrangement, we compared VDJ recombination in transgenic mice carrying two versions of a human TCR-delta gene minilocus recombination substrate. One includes a wild-type E delta, whereas the other carries an E delta with a mutation that abrogates c-Myb binding. We demonstrate that an intact Myb binding site is necessary for efficient rearrangement of the minilocus substrate, suggesting that c-Myb plays a crucial role in activating VDJ recombination at the endogenous TCR-delta locus. |
