| First Author | Ward A | Year | 1995 |
| Journal | Gene | Volume | 167 |
| Issue | 1-2 | Pages | 239-43 |
| PubMed ID | 8566784 | Mgi Jnum | J:30663 |
| Mgi Id | MGI:78166 | Doi | 10.1016/0378-1119(95)00645-1 |
| Citation | Ward A, et al. (1995) Repression of promoters for the mouse insulin-like growth factor II-encoding gene (Igf-2) by products of the Wilms' tumour suppressor gene wt1. Gene 167(1-2):239-43 |
| abstractText | We have investigated actions of the Wilms' tumour suppressor zinc finger transcription factor, WT1, on promoters of the mouse insulin-like growth factor II-encoding gene (Igf-2). Two variant forms of WT1 repressed the two major Igf-2 promoters (P2 and P3) in transient transfection assays. WT1-binding sites were characterised in both these promoters and in the transcribed region downstream from P2, exon 2. In each of these regions, there was a pair of WT1-binding sites, and mutational analysis of the exon-2 sites indicated that both were required for full repression. Cooperative binding of WT1 to these sites might explain the dominant-negative mutations of WT1 observed in some Wilms' tumours and Denys-Drash syndrome cases. |
