| First Author | Hein L | Year | 1995 |
| Journal | Genomics | Volume | 30 |
| Issue | 2 | Pages | 369-71 |
| PubMed ID | 8586443 | Mgi Jnum | J:29924 |
| Mgi Id | MGI:77449 | Doi | 10.1006/geno.1995.0033 |
| Citation | Hein L, et al. (1995) Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome. Genomics 30(2):369-71 |
| abstractText | Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors. While the type 1 receptor (AT1) mediates the cardiovascular actions of angiotensin II, the function of the recently cloned type 2 receptor (AT2) remains unknown. We have cloned the mouse AT2 receptor gene (Agtr2) and determined its map position by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus).Agtr2 is located on the proximal mouse X chromosome between DXMit85 and DXMit49, in a region of conserved synteny with a part of the human X chromosome implicated in inherited forms of premature ovarian failure. The mapping of Agtr2 may expand a region of conserved synteny with human Xq26 that includes Hprt. |
