| First Author | Wernig A | Year | 1995 |
| Journal | J Neurol Sci | Volume | 130 |
| Issue | 2 | Pages | 190-6 |
| PubMed ID | 8586985 | Mgi Jnum | J:27209 |
| Mgi Id | MGI:74628 | Doi | 10.1016/0022-510x(95)00034-y |
| Citation | Wernig A, et al. (1995) Bystander damage of host muscle caused by implantation of MHC-compatible myogenic cells. J Neurol Sci 130(2):190-6 |
| abstractText | Transplantation of normal myoblasts has been considered a potential therapy for muscle dystrophies. While survival of implanted cells has been described in animal experiments and in human trials, functional effects remained unclear. Here we report on survival of progenors of implanted C2nlsBAG cells in regenerating muscles but irreversible net loss in muscle tissue and contractile force. This is caused by immune rejection of implanted myoblasts despite MHC-compatibility and bystander damage of host muscle tissue. |
