| First Author | del Marmol V | Year | 1996 |
| Journal | FEBS Lett | Volume | 381 |
| Issue | 3 | Pages | 165-8 |
| PubMed ID | 8601447 | Mgi Jnum | J:32755 |
| Mgi Id | MGI:80245 | Doi | 10.1016/0014-5793(96)00109-3 |
| Citation | del Marmol V, et al. (1996) Tyrosinase and related proteins in mammalian pigmentation. FEBS Lett 381(3):165-8 |
| abstractText | Tyrosinase is the key enzyme in pigment synthesis, initiating a cascade of reactions which convert the amino acid tyrosine to the melanin biopolymer. Two other tyrosinase-related proteins (TRP) are known, TRP-1 (probably DHICAoxidase) and TRP-2 (DOPAchrome tautomerase). These proteins show about 40% homology, and recent results have indicated that the genes might be derived from a common ancestor. We will discuss recent findings on genomic organization, and on the proteins and their presumed function, which is important for eumelanin synthesis in mouse and man. |
