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Publication : Differential activation of the murine laminin B1 gene promoter by RAR alpha, ROR alpha, and AP-1.

First Author  Matsui T Year  1996
Journal  Biochem Biophys Res Commun Volume  220
Issue  2 Pages  405-10
PubMed ID  8645318 Mgi Jnum  J:32085
Mgi Id  MGI:79590 Doi  10.1006/bbrc.1996.0418
Citation  Matsui T (1996) Differential activation of the murine laminin B1 gene promoter by RAR alpha, ROR alpha, and AP-1. Biochem Biophys Res Commun 220(2):405-10
abstractText  RAR alpha, ROR alpha and AP-1 activated the transcription of the murine laminin B1 gene promoter, which consists of three core elements. Cotransfection experiments showed that AP-1-activated transcription is further stimulated by RAR alpha, but not by ROR alpha. Additionally, it was demonstrated by promoter mutagenesis that all of the three core elements are required for transactivation by RAR alpha and ROR alpha, while any one of them is dispensable for AP-1-activated transcription. These results suggest that the modes of transactivation of the laminin B1 promoter are different among the three transactivators.
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