| First Author | Lee MS | Year | 1996 |
| Journal | Transplantation | Volume | 61 |
| Issue | 7 | Pages | 1112-5 |
| PubMed ID | 8623195 | Mgi Jnum | J:32562 |
| Mgi Id | MGI:80056 | Doi | 10.1097/00007890-199604150-00022 |
| Citation | Lee MS, et al. (1996) Transforming growth factor-beta fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice. Transplantation 61(7):1112-5 |
| abstractText | Transgenic mice whose pancreata express transforming growth factor-beta (TGF-beta) directed by an insulin promoter (Ins-TGF-beta mice) were used to assess the effect of local TGF-beta1 on allograft rejection and on autoimmune diabetes occurring as a cross-reaction to viral antigens. Pancreatic TGF-beta1 did not delay allograft rejection, nor did it inhibit autoimmune diabetes after lymphocytic choriomeningitis infection of double transgenic mice (LCMV/TGF-beta1 mice). These results suggest that local TGF-beta1 does not serve as an immunosuppressive agent for allograft rejection or virus-mediated autoimmune diabetes. |
