| First Author | Fennelly J | Year | 1996 |
| Journal | Genomics | Volume | 33 |
| Issue | 1 | Pages | 94-8 |
| PubMed ID | 8617515 | Mgi Jnum | J:32419 |
| Mgi Id | MGI:79914 | Doi | 10.1006/geno.1996.0163 |
| Citation | Fennelly J, et al. (1996) A polymorphic and hypervariable locus in the pseudoautosomal region of the CBA/H mouse sex chromosomes. Genomics 33(1):94-8 |
| abstractText | We have identified a genomic locus (DXYH1) that is polymorphic and hypervariable within the CBA/H colony. Using a panel of C57BL/6 x Mus spretus backcross offspring, it was mapped to the distal end of the X chromosome. Pseudoautosomal inheritance was demonstrated through three generations of CBA/H x CBA/H and CBA/H x C57BL/6 crosses and confirmed through linkage to the Sxr locus in X/Y Sxr x 3H1 crosses. Meiotic recombination frequencies place DXYH1 similar to 28% into the pseudoautosomal region from the boundary. The de novo generation of CBA/H variant DXYH1 restriction fragment length polymorphisms during spermatogenesis is suggestive of the germline instability associated with hypermutable human minisatellites. The absence of DXYH1-related sequences in Mus spretus provides DNA sequence evidence to support the observed failure of X-Y pairing during meiosis and consequent hybrid infertility in C57BL/6 x Mus spretus male F1 offspring. (C) 1996 Academic Press, Inc. |
