| First Author | Van Parijs L | Year | 1996 |
| Journal | Immunity | Volume | 4 |
| Issue | 3 | Pages | 321-8 |
| PubMed ID | 8624822 | Mgi Jnum | J:31933 |
| Mgi Id | MGI:79437 | Doi | 10.1016/s1074-7613(00)80440-9 |
| Citation | Van Parijs L, et al. (1996) The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 4(3):321-8 |
| abstractText | Using cells from TCR transgenic mice that do or do not express Fas, we show that there are two mechanistically distinct forms of apoptosis in CD4+ T cells. Naive T cells undergo apoptosis if cultured in the absence of antigen or costimulation. This form of programmed cell death (PCD) is not dependent on Fas, and is prevented by CD28-mediated signals, which lead to the secretion of growth factors and the expression of survival genes, such as bcl-xL. Recently activated T cells undergo apoptotic death upon repeated stimulation. This activation-induced cell death (AICD) is mediated by Fas, but is independent of costimulation and is not prevented by IL-2 or bcl-xL. Finally, we show that peripheral tolerance may be induced in vivo independent of Fas-mediated cell death. |
