| First Author | Taga T | Year | 1996 |
| Journal | J Neurochem | Volume | 67 |
| Issue | 1 | Pages | 1-10 |
| PubMed ID | 8666978 | Mgi Jnum | J:33647 |
| Mgi Id | MGI:81125 | Doi | 10.1046/j.1471-4159.1996.67010001.x |
| Citation | Taga T (1996) Gp130, a shared signal transducing receptor component for hematopoietic and neuropoietic cytokines. J Neurochem 67(1):1-10 |
| abstractText | Most of the receptors for soluble factors functioning in the hematopoietic system belong to the class I cytokine receptor family. These receptors often share common signal transducing receptor components in the same family, which explains the functional redundancy of cytokines. One typical example is a group of receptor systems for interleukin-6 (IL-6) and related cytokines that share gp130 as a signal transducer. This subset of cytokines, i.e., IL-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1, are all pleiotropic, exhibiting overlapping biological activities, and are known to function also in the neuronal system. In their receptor complexes, gp130 and ligand-specific chains possess no intrinsic tyrosine kinase domain but are associated with members of the Jak family of cytoplasmic tyrosine kinases. The Jak kinases become activated after ligand-induced homo- or heterodimerization of gp130. This activation appears to link the cell surface receptors to the nuclear genes through a series of biochemical changes, including tyrosine phosphorylation and activation of a latent cytoplasmic transcription factor called signal transducer and activator of transcription 3 (STAT3). |
