| First Author | Wlodraczyk B | Year | 1996 |
| Journal | Dev Genet | Volume | 18 |
| Issue | 4 | Pages | 306-15 |
| PubMed ID | 8754282 | Mgi Jnum | J:33847 |
| Mgi Id | MGI:81340 | Doi | 10.1002/(SICI)1520-6408(1996)18:4<306::AID-DVG4>3.0.CO;2-D |
| Citation | Wlodraczyk B, et al. (1996) Arsenic-induced alterations in embryonic transcription factor gene expression: implications for abnormal neural development. Dev Genet 18(4):306-15 |
| abstractText | We examined the morphological and molecular consequences of acute in utero exposure to teratogenic concentrations of arsenate. The treatment produced a dose-related increase in neural tube defects, along with a significant alteration in the pattern of gene expression for several transcription factors (creb, Hox 3.1, Pax3, and Emx-1) that were examined using in situ transcription and antisense RNA amplification procedures. On gestational day 9:0, there was a significant delay in the embryos progression through neural tube closure, accompanied by a significant downregulation of Hox 3.1 expression and a significant upregulation of Pax3, Emx-1, and creb. As both Hox 3.1 and Pax3 serve to regulate N-CAM expression, it is possible that abnormalities associated with N-CAM may compromise neural crest cell migration and normal neural tube closure. |
