First Author | Plougastel B | Year | 1996 |
Journal | Immunogenetics | Volume | 44 |
Issue | 4 | Pages | 286-91 |
PubMed ID | 8753859 | Mgi Jnum | J:35148 |
Mgi Id | MGI:82599 | Doi | 10.1007/BF02602558 |
Citation | Plougastel B, et al. (1996) Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene. Immunogenetics 44(4):286-91 |
abstractText | A cosmid containing the human NKG2A gene was isolated. The gene was partially sequenced, revealing 7 exons, including one 5' untranslated exon. The 54 base pair exon 5 was missing in the published cDNA clone NKG2B, consistent with the existence of differential splicing. This was confirmed by reverse transcription-polymerase chain reaction of total RNA from normal lymphocytes. The NKG2A gene was mapped by FISH to chromosome 12p12. 3-p13.1 in proximity to the CD69 and Prp genes. These data support the presence of a human lectin-like NK gene complex, analogous to the NK complex on mouse chromosome 6. |