| First Author | Díaz-Meco MT | Year | 1996 |
| Journal | Cell | Volume | 86 |
| Issue | 5 | Pages | 777-86 |
| PubMed ID | 8797824 | Mgi Jnum | J:35282 |
| Mgi Id | MGI:82732 | Doi | 10.1016/s0092-8674(00)80152-x |
| Citation | Diaz-Meco MT, et al. (1996) The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell 86(5):777-86 |
| abstractText | The atypical PKCs are involved in a number of important cellular functions, including cell proliferation. We report here that the product of the par-4 gene specifically interacts with the regulatory domains of zeta PKC and lambda/LPKC, which dramatically inhibits their enzymatic activity. This is particularly challenging, because expression of par-4 has been shown to correlate with growth inhibition and apoptosis. Results are shown here demonstrating that the expression of par-4 in NIH-3T3 cells induces morphological changes typical of apoptosis, which are abrogated by cotransfection of either wild-type zeta PKC or lambda/LPKC, but not by their respective kinase-inactive mutants. These findings support a role for the atypical PKC subspecies in the control of cell growth and survival. |
