| First Author | Edwards YH | Year | 1996 |
| Journal | Genome Res | Volume | 6 |
| Issue | 3 | Pages | 226-33 |
| PubMed ID | 8963900 | Mgi Jnum | J:32564 |
| Mgi Id | MGI:80058 | Doi | 10.1101/gr.6.3.226 |
| Citation | Edwards YH, et al. (1996) The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27. Genome Res 6(3):226-33 |
| abstractText | We have cloned the human gene encoding the transcription factor T. T protein is vital for the formation of posterior mesoderm and axial development in all vertebrates. Brachyury mutant mice, which lack T protein, die in utero with abnormal notochord, posterior somites, and allantois. We have identified human T genomic clones and derived the mRNA sequence and gene structure. There is 91% amino acid identity between human and mouse T proteins overall and complete identity across 77 amino acids of the T-box motif within the DNA-binding domain. Human T expression is very similar to that found for T in other vertebrate species and is confined to cells derived from the notochord. The human T gene maps to chromosome 6q27 and is only the second human member of the T-box gene family to be described. |
