| First Author | Lonigro R | Year | 1996 |
| Journal | Cell Growth Differ | Volume | 7 |
| Issue | 2 | Pages | 251-61 |
| PubMed ID | 8822209 | Mgi Jnum | J:31794 |
| Mgi Id | MGI:79288 | Citation | Lonigro R, et al. (1996) Expression of thyroid transcription factor 1 gene can be regulated at the transcriptional and posttranscriptional levels. Cell Growth Differ 7(2):251-61 |
| abstractText | The complete structure of the gene for thyroid transcription factor 1 (TTF-1), both in rats and humans, has been determined. The rat TTF-1 gene shows three transcriptional start sites and contains two introns, one of which is alternatively spliced. Nuclear run-on and transient transfection experiments indicate that TTF-1 gene expression can be controlled at different levels. Using thyroid and nonthyroid cell lines, it can be shown that transcriptional mechanisms are involved in controlling thyroid-specific expression of the TTF-1 gene. In contrast, in thyroid cells expressing an activated Ki-ras oncogene, the steady-state level of TTF-1 mRNA is greatly reduced, while transcription of the TTF-1 gene is only moderately affected, suggesting that the accumulation of TTF-1 mRNA can be regulated by a posttranscriptional, Ras-sensitive mechanism. |
