| First Author | Jinno Y | Year | 1996 |
| Journal | Hum Mol Genet | Volume | 5 |
| Issue | 8 | Pages | 1155-61 |
| PubMed ID | 8842735 | Mgi Jnum | J:34516 |
| Mgi Id | MGI:81972 | Doi | 10.1093/hmg/5.8.1155 |
| Citation | Jinno Y, et al. (1996) Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus. Hum Mol Genet 5(8):1155-61 |
| abstractText | We have identified a region with characteristics of a paternal-specific methylation imprint at the human H19 locus. This region, extending from -2.0 kb upstream to the start of transcription, is heavily methylated in sperm and on the paternal allele in somatic cells. This methylation was preserved during pre-implantation. Structural analysis revealed the presence of CpG islands and a large direct repeat with a 400 bp sequence reiterated several times, but no significant sequence homology to the corresponding region of the mouse H19 gene. These findings could suggest a role for secondary DNA structure in genomic imprinting across the species, and they also present a puzzling aspect of the evolution of the H19 regulatory region in human and mouse. |
