| First Author | Van Antwerp DJ | Year | 1996 |
| Journal | Science | Volume | 274 |
| Issue | 5288 | Pages | 787-9 |
| PubMed ID | 8864120 | Mgi Jnum | J:36490 |
| Mgi Id | MGI:83917 | Doi | 10.1126/science.274.5288.787 |
| Citation | Van Antwerp DJ, et al. (1996) Suppression of TNF-alpha-induced apoptosis by NF-kappaB [see comments]. Science 274(5288):787-9 |
| abstractText | Tumor necrosis factor alpha (TNF-alpha) signaling gives rise to a number of events, including activation of transcription factor NF-kappaB and programmed cell death (apoptosis). Previous studies of TNF-alpha signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-alpha-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IkappaBalpha (IkappaBalphaM). These findings suggest that a negative feedback mechanism results from TNF-alpha signaling in which NF-kappaB activation suppresses the signals for cell death. |
