| First Author | Macdonald R | Year | 1996 |
| Journal | Curr Opin Neurobiol | Volume | 6 |
| Issue | 1 | Pages | 49-56 |
| PubMed ID | 8794051 | Mgi Jnum | J:33969 |
| Mgi Id | MGI:81449 | Doi | 10.1016/s0959-4388(96)80008-0 |
| Citation | Macdonald R, et al. (1996) Pax proteins and eye development. Curr Opin Neurobiol 6(1):49-56 |
| abstractText | Homologous members of the Pax gene family are required for eye development in Drosophila and vertebrates. Despite superficial similarities in the phenotypes of vertebrates with mutations in pax-6 and Drosophila eyeless mutants, it remains uncertain whether the two proteins encoded by these genes have comparable functions. The genetic cascade triggered by eyeless leads to eye formation, whereas pax-6 is not necessary for optic vesicle formation, but is required at other stages of eye development. A second vertebrate Pax gene, pax-2, is also required during eye development and appears to play a role during closure of the choroid fissure. |
