| First Author | Ando Y | Year | 1996 |
| Journal | Immunobiology | Volume | 195 |
| Issue | 3 | Pages | 376-84 |
| PubMed ID | 8877410 | Mgi Jnum | J:38588 |
| Mgi Id | MGI:85967 | Doi | 10.1016/S0171-2985(96)80053-2 |
| Citation | Ando Y, et al. (1996) CD4 expression is important but not essential for infection with exogenous mouse mammary tumor virus. Immunobiology 195(3):376-84 |
| abstractText | We studied local events in the popliteal lymph nodes of CD4-deficient mice following foot pad injection with an MMTV strain which carries the gene for a V beta 14-specific superantigen. Injection of the V beta 14-specific MMTV induced vigorous expansion of V beta 14+ CD4+ T cells and B cells in their lymph nodes of CD4+/- heterozygous control mice. On the other hand, CD4-/- mice injected with the MMTV showed a proliferation of V beta 14+ T cells among the population of TCR alpha beta + CD4-CD8- T cells, although to a lesser extent. This phenomenon was not accompanied by vigorous B cell expansion. A PCR assay revelated that the MMTV definitely infected the lymph nodes cells of the CD4-/- mouse. However, the infectivity of the MMTV in CD4-/- mice was approximately 20 times lower than that in CD4+/- mice. These findings indicate that, in MMTV infection of CD4-deficient mice, the superantigen-reactive T cells among the population of TCR alpha beta +CD4-CD8- T cells substitute for the superantigen-reactive CD4- T cells of normal mice, and that the absence of CD4 molecules decreased the infectivity of MMTV because of insufficient expansion of the superantigen-reactive T cells. |
