| First Author | Wang C | Year | 1996 |
| Journal | Gene | Volume | 174 |
| Issue | 2 | Pages | 299-306 |
| PubMed ID | 8890751 | Mgi Jnum | J:35892 |
| Mgi Id | MGI:83335 | Doi | 10.1016/0378-1119(96)00080-7 |
| Citation | Wang C, et al. (1996) The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains. Gene 174(2):299-306 |
| abstractText | A full-length human RHAMM cDNA clone was isolated by a combination of screening a human breast cDNA expression library with the murine RHAMM 2 cDNA as well as 5' RACE and RT-PCR using messenger RNA from human breast cell line (MCF-10A). The full-length cDNA contained 725 aa that encoded an 84 kDa protein. Although the coding region of the human RHAMM cDNA resembles the murine RHAMM v4, it has additional unique N-terminal (489 bp) and C-terminal (33 bp) regions. Also, only 1 of 5 repeat sequences encoded in the murine cDNA are present in human cDNA. The overall homology between the overlapping region of human and mouse RHAMM v4 cDNA clone is 85%, but the HA binding motif (B[X7]B), shown to be critical for the signaling capability of this receptor, is 100% conserved. |
