| First Author | Miyajima M | Year | 1996 |
| Journal | J Neurosci Res | Volume | 46 |
| Issue | 1 | Pages | 108-13 |
| PubMed ID | 8892111 | Mgi Jnum | J:35608 |
| Mgi Id | MGI:83056 | Doi | 10.1002/(SICI)1097-4547(19961001)46:1<108::AID-JNR13>3.0.CO;2-1 |
| Citation | Miyajima M, et al. (1996) Overexpression of E2F1 in astrocytes leads to neoplastic transformation and changes in expression of retinoblastoma family members. J Neurosci Res 46(1):108-13 |
| abstractText | Overexpression of mouse E2F1 full-length but not truncated forms results in neoplastic transformation of astrocytes in vitro. This neoplastic transformation is accompanied with changes in cell morphology and expression of cell cycle regulators. Transformed astrocytes have higher expression of cdk2, pRb, and p107 than control astrocytes. However, expression of glial fibrillary acidic protein (GFAP) and p130 is reduced in transformed astrocytes. |
